In this study, we investigated the joint effect of GPR and TME on STS, first using differential expression analysis, univariate Cox regression analysis, LASSO algorithm, and multivariate Cox regression analysis, and identified a total of seven genes (CPXM1, CD48, GPR132, PRF1, CTSW, TBC1D10C, and PLEKHO2) related to STS prognosis and constructed a seven-GPR risk signature. This evidence concerns the gene PRF1 and telomere syndrome.