A previous study showed that ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression of these leukemia cells, indicating that GPR signaling contributes to AML pathogenesis and that ADCY7 supports the development of AML; the inhibition of ADCY7 may be a novel treatment strategy for AML (44). This evidence concerns the gene ALDH18A1 and leukemia.