Figure 7D details the mutations in 8 depression-related genes incorporated into the predictive model, including TAP1, CD244, CSF1, FCGR2B, SPP1, and IL-10. A significant difference in TMB levels between the two groups was observed, with risk scores exhibiting a positive correlation with TMB values (Figure 7E). The gene discussed is SPP1; the disease is depressive symptom measurement.