Notably, the C. tropicalis strain MYA-3404, but not clinical isolates from Crohn’s disease patients, is a potent inducer of IL-17A from Th17 and γδ T cells, as well as IL-22 from ILC3s, thereby enhancing intestinal barrier function by promoting epithelial cell proliferation and inducing goblet cell differentiation (63). This evidence concerns the gene IL17A and Crohn disease.