Among ES-SCLC patients, those with normal serum total IgE levels showed the lowest median PFS (normal, 6.17 months; borderline, 11.53 months; elevated, 9.47 months; P=0.3143), whereas those with elevated serum total IgE level showed the lowest median OS (normal, 27.03 months; borderline, 16.80 months; elevated, 14.37 months; P=0.3606), but the results were not statistically significant (Figures 3A, B). Here, IGHE is linked to small cell lung carcinoma.