Multivariate logistic regression analysis results showed that age ≥65 years (OR=4.775, 95% CI = 3.478–6.555; P <0.001), smoking history (OR=1.719, 95% CI = 1.198–2.466; P =0.003), and an elevated lymphocyte-to-monocyte ratio (LMR) (OR=0.777, 95% CI = 0.678–0.890; P <0.001) were independent risk factors for lung cancer development in subjects with serum total IgE levels >100 IU/ml. The gene discussed is IGHE; the disease is lung cancer.