Among stage IV NSCLC patients, those with normal serum total IgE level showed the lowest median PFS (normal, 12.83 months; borderline, 17.30 months; elevated, 16.30 months; P=0.4467) and the lowest median OS (normal, 32.13 months; borderline, 46.37 months; elevated, 33.67 months; P=0.4481), but the results were not statistically significant (Figures 3C, D). This evidence concerns the gene IGHE and non-small cell lung carcinoma.