Upon encountering tumor-associated molecular signatures and receiving cues from the immune milieu, eosinophils undergo degranulation, releasing a spectrum of effector molecules—such as TNF-α, granzymes, major basic protein (MBP), and metalloproteinases—that facilitate immune cell recruitment, enhance antigen presentation, and directly induce tumor cytotoxicity (34, 35). This evidence concerns the gene TNF and neoplasm.