PTGER3 and Hepatic fibrosis: In addition to the mentioned modulation of receptor-ligand to increase the sensitivity of NK-HSCs recognition to promote NK killing, interference with external factors such as CTLA-4-associated T cells, prostaglandin E receptor 3 (EP3), dihydromyricetin (DHM), microRNA, can help to enhance NK killing of HSCs to inhibit liver fibrosis.