In contrast, monocyte-derived macrophages (MdM) infiltrating in metabolic dysfunction-associated steatohepatitis (MASH) are heterogeneous, which involves lipid-associated macrophage (LAM) expressing TREM2, Gpnmb, OPN1, CD63 and CD9 (Daemen et al., 2021), one assemble into macrophage aggregates around dying hepatocytes, forming hepatic corona-like structures (hCLS), which localize in areas filled with HSCs to promote fibrosis. The gene discussed is TREM2; the disease is metabolic dysfunction-associated steatohepatitis.