In NASH livers enriched with C-X-C motif chemokine receptor 6(CXCR6) CD8 T cells with low activity of the forkhead box protein O1(FoxO1) transcription factor, cells can be auto-aggressively killed in an MHC class I non-dependent manner via signals from the P2X7 purinergic receptor. Here, CD8A is linked to metabolic dysfunction-associated steatohepatitis.