Kruppel-like factor 2 (KLF2), a transcription factor capable of positively regulating the eNOS-sGC pathway maintains LSECs differentiation, has been demonstrated to facilitate the inactivation of HSCs activation and apoptosis to alleviate liver fibrosis by Simvastatin (Marrone et al., 2015). Here, KLF2 is linked to Hepatic fibrosis.