The Notch signaling pathway plays an essential role in maintaining hepatic sinusoidal and hepatocyte homeostasis, whereas the activation of the NOTCH pathway in LSECs inhibits the eNOS/sGC signaling pathway, resulting in the promotion of LSECs capillarization, impairment of liver regeneration, and hepatic fibrosis progression (Duan et al., 2018). The gene discussed is SGCB; the disease is Hepatic fibrosis.