Single-cell transcriptome analysis and fluorescence-activated cell sorter (FACS) analysis of NASH mouse models revealed that hepatic CD8 tissue-resident memory CD8 T (CD8 Trm) cells maintained by tissue IL-15 attracted HSCs in a CCR5-dependent manner and predisposed aHSCs to FasL-Fas-mediated apoptosis (Koda et al., 2021). This evidence concerns the gene CD8A and metabolic dysfunction-associated steatohepatitis.