Three promising autophagy-associated differentially expressed genes as therapeutic biomarkers for hepatic fibrosis, including autophagy - related 5 (ATG5), retinoblastoma inducible coiled-coil protein 1 (RB1CC1) and PARK2, among which RB1CC1 may promote the progression of liver fibrosis by regulating macrophages, Th17 cells, NK cells and CD56dim natural killer cells (Huang et al., 2024). This evidence concerns the gene RB1CC1 and Hepatic fibrosis.