HES1 and Hepatic fibrosis: Experiments displayed that in the hepatic fibrosis mice model with POFUT1 knockout in LSECs, POFUT1 deficiency inhibited the KLF2-eNOS-sGC signaling axis, promoting injury-induced LSEC capillarization, while up-regulating the expression of fibrinogen in LSEC through the NOTCH/HES1/STAT3 pathway.