During angiogenesis in the early stages of hepatic fibrosis, the mechanical tension generated by the contraction of LSECs was transmitted via collagen, which triggers the DDR2-JAK2/PI3K/AKT-cardiac muscle protein signaling pathway to initiate HSCs activation and ultimately augment the progression of hepatic fibrosis (Liu et al., 2017). Here, JAK2 is linked to Hepatic fibrosis.