In a thioacetamide-treated mouse model, the expression of liver fibrosis markers and inflammatory responses mediated by macrophages was suppressed after the inhibition of HMGB1, TLR4 and the assembly of NLRP3/ASC inflammasomes induced by LPS/ATP in mouse peritoneal macrophages (Yao et al., 2024). This evidence concerns the gene NLRP3 and Hepatic fibrosis.