iHSCs subpopulation in intrahepatic cholangiocarcinoma (iCCA) secretes HGF, which promotes tumor growth, while in another model of iCCA, myofibroblast CAF subpopulation can secrete type I collagen, which contributes to tumor stiffness without affecting tumor growth; however, myCAF also secretes hyaluronidase 2 (HA2), which promotes the growth and development of iCCA without affecting the stiffness of ECM (Affo et al., 2021). Here, HYAL2 is linked to neoplasm.