In most cases, γδ T cells, especially the γδT1 subpopulation, have a very potent cytotoxic effect on HSCs, by producing IFN-γ (Hammerich et al., 2014), or with the help of chronic hepatitis-promoted expression of NKp46 to directly kill aHSCs (Liu M. et al., 2019), which at the same time increases the cytotoxicity of NK cells against aHSCs to fight fibrosis. This evidence concerns the gene IFNG and chronic hepatitis.