MAPT and Alzheimer disease: The main pathological features of AD include the accumulation of β-amyloid (Aβ) forming extracellular senile plaques (SPs) and the hyperphosphorylation of the microtubule-associated protein tau (MAPT) forming intracellular neurofibrillary tangles (NFTs) (Graff-Radford et al., 2021).