Studies (Corcoran et al., 2010; Jin et al., 2017) show that sodium selenate reduces Tau phosphorylation in vivo and in vitro by activating serine/threonine-specific protein phosphatase 2A (PP2A), rescuing cognitive deficits in Tau transgenic mice (e.g., P301L, K369I, and Tau441 models). This evidence concerns the gene PTPA and Cognitive impairment.