GPX4 and Cognitive impairment: A study (Hambright et al., 2017) showed that GPX4-knockout AD mouse models exhibited reduced hippocampal and cortical neuronal proteins and increased LPO, which were reversed by the lipophilic antioxidant vitamin E. This indicates that GPX4 ameliorates ferroptosis-induced neurodegeneration and cognitive impairment, alleviating synaptic loss and neuronal dysfunction in AD.