A study (Wu M. et al., 2021) showed that high concentrations of Aβ lead to a reduction in recombinant human lymphocyte antigen 6H (Ly6h), an increase in Ca2+ influx mediated by α7-nAChR, and increased Tau hyperphosphorylation and neurotoxicity in the brains of AD patients. Here, CHRNA7 is linked to Alzheimer disease.