ORM1 and obesity due to melanocortin 4 receptor deficiency: A pathophysiological state that produces chronic low-grade inflammation is obesity, in which adipocytes produce adipokines, such as adiponectin, leptin, IL-6, TNF alpha, resistin, angiotensinogen, C-reactive protein, and AGP1 in a chronic manner, through signaling elevated levels of glucose, insulin, and free fatty acids; thus, adipose tissue is considered a regulator of physiological processes, such as immunity and inflammation, where AGP1 is involved in these biological events by protecting adipose tissue from excessive inflammation and metabolic dysfunction [13, 14].