To gain a comprehensive understanding of the demographic factors and laboratory biomarkers’ impact on ARDS in COVID-19, we conducted a correlation analysis between age, BMI, CRP, hematological biomarkers (neutrophil, lymphocyte, and NLR), and cytokines (IL-10 and TNF-α), with PaO2/FiO2. The gene discussed is TNF; the disease is COVID-19.