If TT gene variant was present in rs3745274 of CYP2B6 in donor, the risk of both nephrotoxicity and DM de novo could increase if concur with TC variant in ABCB1 rs2235033 of recipient or AG variant in SLCO1B1 rs2306283 of donor, respectively (OR: 7.5 and 9.8). This evidence concerns the gene CYP2B6 and diabetes mellitus.