The anti‐tumor action of an ester of phloridzin is allied to the down‐regulation of the anti‐apoptotic gene (BCL2), several growth factor receptors (EBFR family, IGF1R/IGF2, PDGFR), their signaling associates (Ras/Raf/MAPK, PI3k/AKT/mTOR), and the machinery of the cell cycle in addition to epigenetic regulators (Nair and Rupasinghe 2014). The gene discussed is AKT1; the disease is neoplasm.