Notably, the anti‐tumor activity of phloridzin was due to the Pleiotropic suppression of proteins such as P62/SQSTM1 and LC3 І/II in the JAK/STAT signaling pathway, which is responsible for oesophagal cancer growth, metastasis, and apoptosis, thus affecting the overall development of cancer cells. This evidence concerns the gene SQSTM1 and neoplasm.