Meanwhile, the measurements of metabolite concentration and enzyme activity showed that intracellular peroxides, including lipid hydroperoxide (LPO) and malondialdehyde (MDA), increased, and the activities of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT), declined in PLB‐treated HCC cells (Figure 3C–F). Here, SOD1 is linked to hepatocellular carcinoma.