Methylation of the tumor suppressor gene RASSF1A [38, 39], one of the most frequently altered genes in cancer, one of the most frequently altered genes in cancer, promotes tumor proliferation, and survival via the Ras/Raf/MAP kinase‐ERK kinase (MEK)/extracellular‐signal‐regulated kinase (ERK) signaling pathway [40]. This evidence concerns the gene RAF1 and neoplasm.