CD8A and systemic lupus erythematosus: For example, a large‐scale multiplexed scRNA sequencing study of 1.2 million adult human peripheral blood mononuclear cells (PBMCs) indicated that SLE monocytes exhibited high expression of interferon (IFN)‐stimulated genes (ISGs), the number of naïve CD4+T cells was reduced and GZMH+CD8+ T cells were expanded in SLE patients [7].