One more important thing is that, compared with male pristane‐induced SLE mice, the above indicators of female pristane‐induced SLE mice displayed more deviations from normal values; while nanoparticle‐delivered Nsun4 siRNA has nearly the same therapeutic effect on male female pristane‐induced SLE mice (Figure S17B–E). Here, NSUN4 is linked to systemic lupus erythematosus.