Moreover, a few case reports or cellular explorations have demonstrated that m6A regulators, such as writers methyltransferase like 3/14, eraser Alkylation repair homolog protein 5, and readers YTH domain family member 2 and insulin like growth factor binding protein 3, are dysregulated in SLE PMBCs and regulate functions of CD4+T cell activation and effector T cell differentiation, providing promising therapeutic targets for SLE [15, 16, 17, 18, 19, 20]. The gene discussed is IGFBP3; the disease is systemic lupus erythematosus.