A recent scRNA‐seq assay combined with sequencing assay for transposase‐accessible chromatin (ATAC‐seq) performed in peripheral CD4+ T cells from SLE patients and HCs identified a CCR7lowCD74high Treg subgroup in SLE patients, which revealed a novel contribution of exhausted T cells in SLE pathogenesis and showed the prospect of joint sequencing analyses in exploring the pathological mechanisms of SLE [10]. This evidence concerns the gene CD4 and systemic lupus erythematosus.