AKT1 and renal fibrosis: Therefore, in the early treatment of CRS, the occurrence of Anoikis should be avoided as early as possible, the activation of MyoFb should be inhibited, and the development of renal fibrosis should be blocked; while after the kidneys have already developed fibrosis, the PI3K/Akt pathway can be used to inhibit the resistance to anoikis, promote MyoFb apoptosis, thereby delaying renal fibrosis.