Netrin-1 regulates the guidance of neuronal axons in humans mainly through the deleted in colorectal cancer (DCC) and UNC-5 receptors (UNC5A, UNC5B, uncoordinated-5C [UNC5C], and UNC5D), as well as other potential receptors, including neogenin, Down syndrome cell adhesion molecule (DSCAM), adenosine receptor A2b (Adora2b), and integrin subunits [8]. This evidence concerns the gene ADORA2B and cancer.