Endpoint levels of markers of cardiac remodelling including the degree of interstitial cardiac fibrosis (r = −0.5491; P = 0.0074), and the stress biomarker NT-proBNP (r = −0.5456; P = 0.0078), had significant inverse linear correlations with GLS (Figure 5A and B, Supplementary data online, Table S2), while the correlation between atrial strain and such pharmacodynamic parameters showed a clear trend (Figure 5, Supplementary data online, Table S2). This evidence concerns the gene NPPB and Interstitial cardiac fibrosis.