APC and gastric cancer: IL-33 overexpression is a distinguishing feature in GC models with Arid1a mutation, as such dramatic upregulation is not observed in other GC models lacking Arid1a mutation, such as those with mutations in Kras, Cdh1, Apc, or Muc6. 32,42,43 Furthermore, although many murine GC models exhibit significant inflammation, Arid1a-mutated mice specifically show marked infiltration of type 2 immunity-associated inflammatory cells alongside pronounced mucinous changes in the current study.