JMJD8 and neoplasm: While existing studies have characterized aberrant JMJD8 overexpression in neoplastic tissues and its association with clinicopathological parameters across diverse malignancies (11), the multifaceted contribution of JMJD8 to BRCA pathogenesis, notably its mechanistic regulation of the tumor immune microenvironment and functional involvement in immune checkpoint-driven evasion pathways, remains to be fully elucidated.