Among the identified genes, AOC1 encodes a copper-containing amine oxidase that catalyzes the deamination of polyamines to produce reactive oxygen species (50), AOC1 is highly expressed and contributes to tumor progression in various tumors, including gastric, prostate, and colorectal cancers, by promoting the AKT, EMT, and JAK/STAT3 signaling pathways (50–53). Here, STAT3 is linked to colorectal cancer.