The possible justification is that elevated LDL affects fibrinolytic activity, increased circulating level of procoagulants such as tissue factor and factor IV, and decreased levels of anticoagulants like anti-thrombin-III and protein C, thus favoring a tendency toward coagulation, impaired fibrinolysis, endothelial wall dysfunction, and persistence thrombi, which are among the feasible mechanisms connecting PAD incidence (9, 29, 32). Here, F3 is linked to peripheral arterial disease.