Based on the observed mechanism of TAM inhibiting antigen presentation, by skillfully utilizing the natural efferocytosis process of macrophages, we constructed an integrated nanomodulator to enable synchronous delivery of abundant tumor antigens and the small‐molecule cysteine protease inhibitor E64 to TAMs, reinvigorating TAMs to present tumor antigen and activate CD8+ T cells. This evidence concerns the gene CTSB and neoplasm.