As shown in Figure 2H, compared to PBS (+) group, (+) represented 6 Gy X‐ray irradiation, the fluorescence intensity of γ‐H2AX in CT26 cells treated with Ft/Hf@Lipo (+) and Ft‐E64/Hf@Lipo (+) containing radiosensitizer Hf significantly increased by 2.6‐fold and 2.7‐fold, respectively, the effective DNA damage was beneficial for generating abundant tumor antigens. Here, H2AX is linked to neoplasm.