At peak liver fibrosis, where CD8 T cell hyperfunction was observed, mice were challenged with subcutaneous (s.c.)implantation of MC38 colon carcinoma cells, followed by anti‐PD‐1 and anti‐CTLA‐4 combined immunotherapy after tumour volumes reached ≈75 mm3 (Figure 5A). This evidence concerns the gene CTLA4 and Hepatic fibrosis.