Based on available GO and KEGG results derived from metaGenes for each aligned GBM cluster, the hypoxia cluster was primarily associated with hypoxia and oxygen level, related to the HIF‐1 signaling pathway; the NFκB cluster was closely linked to mineral metabolism and gliogenesis; the MAPK cluster was associated with chaperone‐mediated protein processing, while the EGFR cluster regulated gliogenesis, neurogenesis, and glial cell differentiation (Figure 5G, Figure S4B–F). This evidence concerns the gene HIF1A and glioblastoma.