CXCL10 and cancer: However, the role of ‎CXCL10 in cancer is highly context-dependent, as its ‎effect can vary significantly ‎depending on tumor type and microenvironment.74 In some cases, ‎tumors manipulate ‎CXCL10 signaling to create an immunosuppressive microenvironment that ‎allows evasion ‎of the immune system and promotes metastasis.