CXCL10 and neoplasm: At the same time, CXCL10 can activate the PI3K/Akt signaling pathway in ‎immune cells such as T cells and NK cells to enhance their survival, proliferation and functionality.35 This increased immune cell activity boosts anti-tumor immunity by enabling these immune cells ‎to survive in the tumor microenvironment, even when confronted with stress signals and immunosuppressive factors in the tumor.