These stromal cells respond to CXCL10 signaling by producing factors that support tumor migration, invasion and vascular remodeling.52 ‎ A pivotal study by Wightman et al.53 showed that CXCL10 produced by stromal cells significantly contributes to metastasis in triple negative breast cancer (TNBC) by promoting motility and extravasation of CXCR3-expressing tumor cells to distant sites, particularly the lung. The gene discussed is CXCR3; the disease is neoplasm.