AKT1 and cancer: The interaction ‎between CXCL10 and the PI3K/Akt signaling pathway plays a crucial role in the immune response, ‎cancer cell survival and overall cancer progression.34 When CXCL10 binds to its receptor CXCR3 ‎on immune or cancer cells, it activates multiple intracellular signaling pathways, including the ‎PI3K/Akt pathway.