AKT1 and cancer: The phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway is a critical signaling mechanism in cancer that plays a central ‎role in the regulation of cell survival, growth, proliferation and metabolism.32 Dysregulation of ‎this pathway is common in various cancers and is a major contributor to tumor development, ‎progression and resistance to therapy.