This suppression could be particularly detrimental in cancers such as melanoma, non-small cell lung cancer (NSCLC) or renal cell carcinoma, where high intratumorally CXCL10 expression is associated with a better prognosis and increased response to immune checkpoint inhibitors such as anti-PD-1 and anti-CTLA-4 antibodies.90,91 In addition, CXCL10 has angiostatic properties, and its blockade may inadvertently promote angiogenesis, allowing tumors to grow and metastasize more efficiently. This evidence concerns the gene CXCL10 and hereditary clear cell renal cell carcinoma.