Conversely, CXCL10 can also attract tumor-associated macrophages (TAMs) with an M2 phenotype that promotes tumor growth through tissue remodeling, angiogenesis and immunosuppression.47,49 CXCL10 modulates the balance between immune activation and suppression by influencing the presence and function of Tregs and MDSCs. The gene discussed is CXCL10; the disease is neoplasm.