SERPINE1 and atherosclerosis: EATs promote atherosclerosis development by releasing proinflammatory and proatherogenic factors, including angiotensinogen (AGT), IL-6, leptin, monocyte chemoattractant protein-1 (MCP-1, also named CCL2), nerve growth factor (NGF), resistin, omentin, plasminogen activator inhibitor-1 (PAI-1, also known as serpin E1), TNFα, and visfatin.