ADPN has become a therapeutic target for multiple diseases, such as Alzheimer's disease, cardiovascular diseases, certain cancers, myocardial ischemia/reperfusion (I/R) injury, nonalcoholic fatty liver disease (NAFLD), neurodegenerative diseases, sarcopenia, and T2DM [147, 148]. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatotic liver disease.