When 4T1OVA and 4T1M3OVA cells were subcutaneously implanted into nude mice, followed by intravenous injection of CD8+ TOT−1 cells, tumor growth was significantly slower in 4T1M3OVA tumor-bearing mice compared to those bearing 4T1OVA tumors (Fig. 5E&F). This evidence concerns the gene CD8A and neoplasm.