OI is primarily a genetic disorder of the connective tissue due to mutations in the genes encoding type I collagen (COL1A1 and COL1A2), which account for approximately 90% of cases.[8] Type I collagen and proteoglycans are key components of the intervertebral disc framework, and are crucial for maintaining their shape and tension. Here, COL1A1 is linked to osteogenesis imperfecta.