Elevated TG levels can inhibit the renal excretion of UA, promoting its accumulation in the body.[15,16] As for TC, which represents the total amount of cholesterol in the blood, high TC levels are often observed in gout patients, especially those with accompanying metabolic disorders or cardiovascular diseases.[17] The underlying mechanisms connecting gout and lipid metabolism disturbances likely involve shared metabolic pathways, such as insulin resistance and chronic low-grade inflammation. The gene discussed is INS; the disease is gout.