In colorectal cancer, it inhibits tumor proliferation and liver metastasis by targeting FGFR3,[31] and in neuroblastoma studies, miR-99b-5p has been shown to enhance the sensitivity to chemotherapeutic drugs such as doxorubicin.[32] These findings complement the KEGG enrichment results of this study (involving ECM remodeling and oxidative stress pathways), suggesting that miR-99b-5p may exert cross-cancer protective effects by regulating the tumor microenvironment. This evidence concerns the gene FGFR3 and colorectal cancer.