Activation of ACSL1 is associated with enhanced tumor cell proliferation, migration, and resistance to oxidative stress.[51] In ulcerative colitis models, ACSL1 can work with CPT1A to promote FAO and M2 macrophage polarization through the PPAR-γ signaling pathway.[52] In conclusion, based on its structural characteristics and metabolic properties as a MUFA, we hypothesize that 5-dodecenoic acid may influence energy metabolism and cell fate in EC by acting through fatty acid metabolism pathways involving CPT1A and ACSL1. This evidence concerns the gene CPT1A and ulcerative colitis.