This transition is characterized by a significant downregulation of E-cadherin expression and an upregulation of N-cadherin and vimentin, leading to a morphological shift from normal epithelial cells to polygonal or pebble-shaped cells.[29] This change results in a marked decrease in cell polarity, a decline in cell-to-cell adhesion, and the gradual disappearance of cell-to-cell connections, paving the way for the subsequent steps of tumor metastasis. This evidence concerns the gene CDH1 and neoplasm.