NPPB and hydrops fetalis: In the 2 studies involving patients with essential HTN and HF, the reduction in serum BNP was 133 pg/mL (Iwahana et al[37]) and 73.9 pg/mL (Naruke et al[38]); in patients without HF, reductions in NTproBNP ranged from 13.9% to 48%.