ROS also affect renal microcirculation by modulating vasoactive substances such as endothelin, adenosine, and nitric oxide.[21] Therefore, a disruptive vicious cycle is created that leads to tubular cell death and associated inflammatory response.[22] Inflammatory markers such as NLR, PLR, and CRP were also identified as predictors of CI-AKI occurrence after interventional procedures.[6–8] SII and SIRI indexes reflect levels of inflammatory response. The gene discussed is CRP; the disease is acute kidney injury.