IL18 and osteonecrosis: An association between the inflammatory cytokine IL-18 and osteonecrosis is found to be negative, indicating that IL-18 may operate as a protective factor against osteonecrosis (IVW OR = 0.97, 95% CI = 0.935–0.999, P = .042) Table S2 (Supplemental Digital Content, https://links.lww.com/MD/P573) and Figure S2 (Supplemental Digital Content, https://links.lww.com/MD/P572) display the reverse MR analysis results.