The analysis revealed that the GCST90027466 gut microbiome type (FUCCAT.PWY.fucose.degradation, β = 0.395 [0.072, 0.72], P = .016) increased the expression of the GCST90002023 immune cell type (CD4 on CM CD4+) and thereby enhanced the risk of SLE. This evidence concerns the gene CD4 and systemic lupus erythematosus.