Our results indicated that FUCCAT.PWY.fucose.degradation increased the risk of SLE by enhancing the expression of central memory CD4+ T cells (CD4 on CM CD4+), while Lachnospiraceae bacterium 3_1_46FAA reduced the risk of SLE by decreasing the expression of CD25 on CD39+ regulatory T (Treg) cells. The gene discussed is CD4; the disease is systemic lupus erythematosus.