When serum albumin levels fall below 3.5 g/dL, the condition can be diagnosed as hypoalbuminemia.[8] Research indicates that with every 1 g/dL decrease in serum albumin concentration, there is an 89% increase in incidence and a 137% rise in mortality rate.[9] Additionally, hypoalbuminemia can disrupt the pharmacokinetics of antibiotics, potentially leading to treatment failure or excessive drug toxicity.[10] Given these insights, accurately predicting the early mortality rate of septic patients with hypoalbuminemia is paramount for timely intervention. This evidence concerns the gene ALB and Hypoalbuminemia.