PLA2R1 and idiopathic membranous glomerulonephritis: Idiopathic membranous nephropathy stands for the majority (80%) for unknown etiology, whereas secondary MN (20%) is linked to systemic disorders involving hepatitis B or C, Lupus Nephritis, neoplasia, or drugs like NSAIDs.[1] Antibodies to phospholipase A2 receptor (PLA2R) expressed in podocytes are likely responsible for 80% of idiopathic membranous nephropathy.[2] MN is pathologically characterized by apparent thickening of the glomerular capillary walls with deposits of immune complex and electron-dense deposits (i.e., spikes) appearing in the subepithelium under electron microscopes.