Susceptibility loci such as HLA-DR8, alongside non-HLA loci including IL12A, IL12RB2, IRF5/TNPO3, ORMDL3/IKZF3, MMEL1, and SPIB, were identified as contributing factors in PBC.[10] Similarly, HLA-DRB1*0301 and HLA-DRB1*0401 were identified as susceptibility genotypes for AIH type-1.[11] This finding highlights the pivotal role of these genetic triggers in predisposing diseases under an autoimmune context. This evidence concerns the gene IL12RB2 and primary biliary cholangitis.