For example, a meta-analysis has shown that menopausal hormone therapy can increase the incidence of BC, with the highest risk observed in those receiving estrogen combined with progestin.[30] Moreover, Peter J. Park et al have identified a common pattern of oncogene amplification through DNA sequencing and data analysis, and they propose estrogen as a mechanistic source of BC.[31] FSH promotes estrogen secretion, which in turn promotes endometrial hyperplasia in preparation for conception. Here, BRD2 is linked to breast cancer.