Through analyzing methyl-seq and RNA-seq data of AOM/DSS mouse model, Guo et al. observed that curcumin hypomethylated inflammation-associated genes, including Duoxa2, Gja1, Icam1, Igfbp4, Itgb2, Lgals9, and Pf4, which were upregulated by AOM/DSS [98]. The gene discussed is IGFBP4; the disease is infectious otitis media.