Non-coding RNAs such as miR-101 deletion leads to EZH2 overexpression, which further accelerates cancer progression, whereas dysregulation of the chromatin remodeling factor SWI/SNF complex is closely associated with the emergence of desmoplasia-resistant prostate cancer and a neuroendocrine phenotype [118, 119]. Here, EZH2 is linked to Familial prostate cancer.