Other studies have revealed that silencing AQP5 expression can promote apoptosis of colorectal tumor cells, and AQP5 expression is related to not only higher TNM stage, lymph node metastasis and distant metastasis, but also the number of peripheral blood circulating tumor cells (CTC) of patients [25]. The gene discussed is AQP5; the disease is metastatic malignant neoplasm in the lymph nodes.