In contrast to the Aspg LKO mice, mice overexpressing Aspg in livers demonstrated the opposite phenotypes as visualized by more glucose intolerance, higher postprandial blood glucose levels and lower insulin levels than the control group (WT + AAV8-ASPG versus WT + AAV8-VEC) (Fig. 4A–C). This evidence concerns the gene ASPG and Glucose intolerance.