AGRP and Hypoglycemia: The transient reduction in saccharin intake may also reflect a temporary influence of peripheral signals that enhance reward-related consummatory behavior via activation of AgRP neurons—such as ghrelin, which progressively increases with continued calorie restriction38, requires AgRP neurons activation to induce food intake5,39,40 (as we confirmed here), and potently affects consummatory behaviors8—but whose effects may later be overridden by additional signals arising from more severe energy deficits, such as hypoglycemia.