Forced fructose metabolism has been reported to impair mitochondrial function and activate the ISR in several tissue contexts, contributing to metabolic disturbances (Softic 2019).SLC2A5, encoding the GLUT5 fructose transporter, was moreover strongly upregulated in affected human adipose tissue in MFN R707W-related lipodystrophy (Rocha 2017). Here, SLC2A5 is linked to lipodystrophy.