ATP2A2/SERCA2 showed disruption/disorganisation within ICM-DM cardiomyocytes, particularly along the Z-discs, vs AMD, with TNNI3 co-localising along the I-band (Figs. 6D–F,M,N and EV8M; Appendix Fig. S3C,D). This evidence concerns the gene TNNI3 and age-related macular degeneration.