COL1A1 and Hyperglycemia: The expression of AEBP1, a protein known for its positive regulation of ECM organisation and fibrosis-related proteins, including COL1A1 and COL1A2, which exhibited RNA–protein correlation/co-regulation in ICM-DM (Blackburn et al, 2018), has been demonstrated to increase in response to hyperglycaemia, high fructose, and lipid concentrations in human hepatocytes (Gerhard et al, 2019).