When focused on individual HF conditions vs AMD, proteomic analysis resulted in 593 downregulated and 654 upregulated proteins in ICM-DM of which, 1098 were only differentially abundant (DA) in the ICM-DM group of ICM, such as regulator of microtubule dynamics (RMDN3), α-actinin 1 (ACTN1), mitochondrial isocitrate dehydrogenase (IDH2), and mitochondrial acetyl-CoA acetyltransferase (ACAT1) (Fig. 2A,D,G; Datasets EV8 and EV11). Here, ACAT1 is linked to age-related macular degeneration.