Succinate-CoA ligase SUCLG1 was the strongest predictor of ICM-DM mitochondrial volume (ρ = 0.958), while mitochondrial creatine kinase (CKMT2) (ρ = 0.948) and fumarate hydratase (FH) (ρ = 0.932) were best for HF. Here, SUCLG1 is linked to diabetes mellitus.