A diabetes-specific targeted analysis showed negatively enriched Z-disc and contractile gene sets enriched due to the downregulation of CASQ2, peripherin (PRPH), nebulette (NEBL), titin-cap (TCAP), and LIM domain-binding proteins LDB3, PDLIM4, and PDLIM5 (Appendix Fig. S2A,B; Dataset EV36). The gene discussed is TCAP; the disease is diabetes mellitus.