The downregulation of components associated with the peroxisome proliferator-activated receptor (PPAR)-α pathway, of long-chain and very-long-chain fatty acid transporters (SLC27A1, CD36), cytosolic fatty acid binding proteins, acyl-CoA synthetases, and proteins involved in FAO, indicates a reduced utilisation of FA in ICM-DM. This evidence concerns the gene PPARA and diabetes mellitus.