Glycolytic muscle aldolase (ALDOA), which binds to F-actin of the sarcomere and regulates cardiac hypertrophy (Clarke and Morton, 1976; Li et al, 2018b), was regularly distributed across the Z-disc in AMD but appeared dislocated in ICM-DM (Fig. EV8E–J; Appendix Fig. S3G,H). This evidence concerns the gene ALDOA and age-related macular degeneration.