Furthermore, downregulated CI may result in other pathological consequences such as increased oxidative stress, hypertrophy, fibrosis, and glycolysis, and cell death via the mTOR signalling pathway (mTOR pathway proteins exclusively upregulated in ICM-DM) (Balsa et al, 2020; Chouchani et al, 2014; Karamanlidis et al, 2013; Perez-Gomez et al, 2020). The gene discussed is MTOR; the disease is diabetes mellitus.