How SAM/SAH binding to this complex induces Bim is yet to be elucidated, however, this study provides a cautionary tale on the widespread use of SAM as a health supplement, i.e. in people with underlying predisposition to systolic heart failure (such as those with hypertension, diabetes, obesity, chronic kidney disease etc.), the use of SAM could seriously complicate the disease outcome. This evidence concerns the gene BCL2L11 and hypertensive disorder.