How SAM/SAH binding to this complex induces Bim is yet to be elucidated, however, this study provides a cautionary tale on the widespread use of SAM as a health supplement, i.e. in people with underlying predisposition to systolic heart failure (such as those with hypertension, diabetes, obesity, chronic kidney disease etc.), the use of SAM could seriously complicate the disease outcome. The gene discussed is BCL2L11; the disease is obesity due to melanocortin 4 receptor deficiency.