Depending on the PCa stage under treatment pressure, EZH2 inhibition can reverse lineage plasticity when cells are in a metastable state post ARPI to a luminal-driven state (Davies et al, 2021a), or push NEPC cells toward a highly differentiated state with increased NE programs (Venkadakrishnan et al, 2024). This evidence concerns the gene EZH2 and posterior cortical atrophy.