The mRNA expression levels of key effector cytokines such as perforin, granzyme A, granzyme B, IFN-γ, and the Fas ligand in CD8+ T-cells were overall negatively correlated with that of Treg genes in CADM1+-tumor cells and infected cells, supporting the importance of the Treg-type transcriptome in the immune regulation of ATL (Fig. 4a). This evidence concerns the gene PRF1 and neoplasm.