In contrast, many interferon-stimulated genes (ISGs) were upregulated in DM compared to NDC, but downregulated in irMyositis when compared to both Mi2 and TIF1γ subtypes; these differentially regulated ISGs encode for transcriptional regulators (IRF7), signal transduction and activation factors (STAT1, ISG15, IFI27, and IFI35), and effector and sensing proteins (MX1, IFIT1, IFITM1, BST2, IFIH1, OAS3, and DDX58). This evidence concerns the gene ISG15 and dermatomyositis.