ADCY3 and obesity due to melanocortin 4 receptor deficiency: A colocalization analysis between the ADCY3 eQTL in monocytes and publicly available GWAS summary statistics including BMI, obesity class I (OB1), and obesity class II (OB2)32 revealed that the identified locus is associated with both ADCY3 expression in monocytes and obesity-related traits with high probability (PP4eQTL vs BMI = 0.825, PP4eQTL vs OB1 = 0.927, and PP4eQTL vs OB2 = 0.921, Fig. 3f).